Redmile 13F annual report

Redmile is an investment fund managing more than $2.72 trillion ran by Jennifer Ciresi. There are currently 77 companies in Mrs. Ciresi’s portfolio. The largest investments include Krystal Biotech Inc and Amicus Therapeutics Inc, together worth $425 billion.

$2.72 trillion Assets Under Management (AUM)

As of 8th May 2024, Redmile’s top holding is 1,508,250 shares of Krystal Biotech Inc currently worth over $268 billion and making up 9.8% of the portfolio value. Relative to the number of outstanding shares of Krystal Biotech Inc, Redmile owns less than approximately 0.1% of the company. In addition, the fund holds 13,257,286 shares of Amicus Therapeutics Inc worth $156 billion, whose value fell 12.5% in the past six months. The third-largest holding is Immunome worth $121 billion and the next is Scholar Rock Hldg Corp worth $114 billion, with 6,419,610 shares owned.

Currently, Redmile's portfolio is worth at least $2.72 trillion. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Redmile

The Redmile office and employees reside in San Francisco, California. According to the last 13-F report filed with the SEC, Jennifer Ciresi serves as the General Counsel and Chief Compliance Officer at Redmile.

Recent trades

In the most recent 13F filing, Redmile revealed that it had opened a new position in Immunome and bought 4,889,554 shares worth $121 billion. This means they effectively own 0.4% of the company. Immunome makes up 5.8% of the fund's Health Care sector allocation and has grown its share price by 148.9% in the past year.

The investment fund also strengthened its position in Scholar Rock Hldg Corp by buying 3,015,684 additional shares. This makes their stake in Scholar Rock Hldg Corp total 6,419,610 shares worth $114 billion.

On the other hand, there are companies that Redmile is getting rid of from its portfolio. Redmile closed its position in Seagen Inc on 15th May 2024. It sold the previously owned 854,013 shares for $151 million. Jennifer Ciresi also disclosed a decreased stake in Krystal Biotech Inc by 0.2%. This leaves the value of the investment at $268 billion and 1,508,250 shares.

One of the largest hedge funds

The two most similar investment funds to Redmile are Sigfig Wealth Management and Silicon Valley Community Foundation. They manage $2.72 trillion and $2.73 trillion respectively.


Jennifer Ciresi investment strategy

Redmile’s portfolio is diversified across 2 sectors. Currently, their heaviest sector is Health Care — making up 76.1% of the total portfolio value. The fund focuses on investments in the United States as 63.6% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are large-cap stocks. Stocks with a size of more than $10 billion in market cap make up 12% of the total holdings value. On the other hand, small-cap stocks make up only 2.6% of the portfolio. The average market cap of the portfolio companies is close to $10.7 billion.

The complete list of Redmile trades based on 13F SEC filings

These positions were updated on May 15th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Krystal Biotech Inc
20.56%
1,508,250
$268,362,923,000 9.85%
Amicus Therapeutics Inc
40.17%
13,257,286
$156,170,829,000 5.73%
Immunome, Inc.
Opened
4,889,554
$120,674,193,000 4.43%
Scholar Rock Hldg Corp
88.59%
6,419,610
$114,012,274,000 4.18%
Fate Therapeutics Inc
1.63%
13,169,057
$96,660,878,000 3.55%
Regenxbio Inc
127.05%
4,551,556
$95,901,285,000 3.52%
Deciphera Pharmaceuticals In
270.16%
5,296,643
$83,316,194,000 3.06%
Kymera Therapeutics, Inc.
33.49%
1,734,089
$69,710,378,000 2.56%
ADC Therapeutics SA
103.26%
15,269,217
$68,558,784,000 2.52%
Stoke Therapeutics, Inc.
154.51%
5,073,049
$68,486,162,000 2.51%
Augmedix Inc
13.91%
16,380,327
$66,995,537,000 2.46%
Nurix Therapeutics, Inc.
49.10%
4,483,016
$65,900,335,000 2.42%
Biohaven Ltd
Opened
1,163,241
$63,617,650,000 2.33%
Beam Therapeutics Inc.
1.61%
1,879,617
$62,102,546,000 2.28%
Zymeworks Inc
Opened
5,560,798
$58,499,595,000 2.15%
LivaNova PLC
36.09%
1,037,780
$58,053,413,000 2.13%
Shattuck Labs, Inc.
0.08%
5,615,489
$50,202,472,000 1.84%
ALX Oncology Holdings Inc.
464.23%
4,326,509
$48,240,575,000 1.77%
Neurogene Inc
Opened
935,252
$47,604,327,000 1.75%
Akero Therapeutics Inc
17.10%
1,858,702
$46,950,813,000 1.72%
Absci Corporation
2.77%
8,253,316
$46,878,835,000 1.72%
Pliant Therapeutics, Inc.
0.92%
3,097,220
$46,148,578,000 1.69%
Silence Therapeutics plc
Opened
2,027,669
$43,797,650,000 1.61%
IDEAYA Biosciences, Inc.
Opened
922,678
$40,487,111,000 1.49%
4d Molecular Therapeutics In
Opened
1,261,427
$40,189,064,000 1.48%
Annexon Inc
57.09%
5,503,190
$39,457,872,000 1.45%
Boston Scientific Corp.
Opened
560,926
$38,417,822,000 1.41%
Celldex Therapeutics Inc.
56.70%
896,454
$37,624,174,000 1.38%
Keros Therapeutics, Inc.
Opened
552,506
$36,575,897,000 1.34%
Catalent Inc.
Opened
632,464
$35,702,593,000 1.31%
Immunovant Inc
Opened
969,621
$31,328,455,000 1.15%
Replimune Group Inc
2.32%
3,729,983
$30,473,961,000 1.12%
Abbott Labs
Opened
262,371
$29,821,088,000 1.09%
IGM Biosciences, Inc.
7.85%
3,072,478
$29,649,413,000 1.09%
Align Technology, Inc.
Opened
87,255
$28,612,660,000 1.05%
Cogent Biosciences, Inc.
Opened
3,962,602
$26,628,685,000 0.98%
89bio Inc
Opened
2,264,566
$26,359,548,000 0.97%
Cigna Group (The)
Opened
65,435
$23,765,338,000 0.87%
Evolent Health Inc
Opened
679,172
$22,270,050,000 0.82%
Verve Therapeutics Inc
12.49%
1,604,515
$21,307,959,000 0.78%
Entrada Therapeutics Inc
34.32%
1,283,735
$18,190,525,000 0.67%
HCA Healthcare Inc
Opened
52,487
$17,505,989,000 0.64%
Elevance Health Inc
62.82%
31,223
$16,190,374,000 0.59%
Ardelyx Inc
Opened
2,194,560
$16,020,288,000 0.59%
Boundless Bio Inc
Opened
1,114,034
$15,874,985,000 0.58%
Stryker Corp.
Opened
43,246
$15,476,446,000 0.57%
Gritstone Bio Inc
17.23%
5,755,075
$14,790,543,000 0.54%
Prime Medicine Inc
Opened
2,074,350
$14,520,450,000 0.53%
Icon Plc
Opened
36,949
$12,413,017,000 0.46%
Progyny Inc
Opened
320,864
$12,240,962,000 0.45%
Ventyx Biosciences Inc
Opened
2,164,126
$11,902,693,000 0.44%
Intuitive Surgical Inc
Opened
29,546
$11,791,513,000 0.43%
Cytokinetics Inc
Opened
161,600
$11,329,776,000 0.42%
Quest Diagnostics, Inc.
Opened
83,849
$11,161,140,000 0.41%
Mckesson Corporation
Opened
20,707
$11,116,553,000 0.41%
Nuvation Bio Inc
12.69%
3,031,009
$11,032,873,000 0.40%
Elanco Animal Health Inc
Opened
676,039
$11,005,915,000 0.40%
Blueprint Medicines Corp
Opened
113,060
$10,724,872,000 0.39%
Penumbra Inc
Opened
44,613
$9,956,729,000 0.37%
Repare Therapeutics Inc.
25.90%
2,016,302
$9,496,782,000 0.35%
Apellis Pharmaceuticals Inc
Opened
155,000
$9,110,900,000 0.33%
Stereotaxis, Inc.
122.44%
3,308,798
$8,635,963,000 0.32%
Cabaletta Bio Inc
36.41%
442,826
$7,554,612,000 0.28%
Lava Therapeutics Nv
26.34%
2,074,372
$6,907,659,000 0.25%
Atara Biotherapeutics Inc
48.38%
9,263,309
$6,428,736,000 0.24%
Invivyd Inc
25.00%
1,440,725
$6,396,819,000 0.23%
RAPT Therapeutics, Inc.
19.01%
662,398
$5,948,334,000 0.22%
AC Immune SA
Opened
2,007,031
$5,940,812,000 0.22%
Establishment Labs Holdings Inc
Opened
114,341
$5,819,957,000 0.21%
Allakos Inc
35.59%
3,451,076
$4,348,356,000 0.16%
Xeris Biopharma Holdings Inc
No change
1,046,587
$2,312,957,000 0.08%
Achilles Therapeutics Plc
No change
1,608,089
$2,010,111,000 0.07%
AlloVir, Inc.
131.73%
1,907,969
$1,440,326,000 0.05%
Adaptimmune Therapeutics Plc
Opened
715,607
$1,130,659,000 0.04%
Standard BioTools Inc
Opened
411,631
$1,115,520,000 0.04%
Hookipa Pharma Inc
76.68%
1,063,769
$757,404,000 0.03%
Alpha Teknova Inc
69.80%
171,453
$433,776,000 0.02%
Seagen Inc
Closed
854,013
$151,109,000
Argenx Se
Closed
385,818
$146,179,000
Horizon Therapeutics Pub L
Closed
913,319
$72,846,000
The Beauty Health Company
Closed
5,186,348
$66,696,000
Centene Corp.
Closed
651,447
$55,119,000
Xenon Pharmaceuticals Inc
Closed
1,639,344
$49,869,000
Immunogen, Inc.
Closed
9,141,045
$41,135,000
Science 37 Holdings Inc
Closed
19,808,234
$39,815,000
Medavail Holdings Inc
Closed
25,192,751
$38,545,000
1Life Healthcare, Inc.
Closed
4,521,825
$35,451,000
Biomarin Pharmaceutical Inc.
Closed
300,000
$24,861,000
Oak Str Health Inc
Closed
1,383,619
$22,747,000
Zymeworks BC Inc
Closed
3,835,818
$20,330,000
Prothena Corp Plc
Closed
736,175
$19,987,000
Nevro Corp
Closed
405,517
$17,774,000
Stevanato Group S.p.A.
Closed
1,115,825
$17,641,000
IVERIC bio Inc
Closed
1,518,900
$14,612,000
Jazz Pharmaceuticals plc
Closed
93,264
$14,550,000
Tandem Diabetes Care Inc
Closed
187,460
$11,096,000
Somalogic Inc
Closed
2,088,639
$9,441,000
Invitae Corp
Closed
3,805,403
$9,285,000
Bioventus Inc
Closed
1,306,339
$8,909,000
The Oncology Institute Inc
Closed
1,736,116
$8,785,000
Privia Health Group Inc
Closed
206,113
$6,002,000
Immatics N.v
Closed
449,661
$3,917,000
Neoleukin Therapeutics, Inc.
Closed
3,436,935
$3,540,000
TCR2 Therapeutics Inc.
Closed
1,094,645
$3,174,000
Atreca Inc
Closed
800,306
$1,433,000
Sonendo, Inc.
Closed
498,131
$857,000
Cytosorbents Corp
Closed
266,365
$583,000
Ayala Pharmaceuticals, Inc.
Closed
341,030
$372,000
No transactions found
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