Pfm Health Sciences, L.P. 13F annual report

Pfm Health Sciences, L.P. is an investment fund managing more than $2.27 trillion ran by Darin Sadow. There are currently 75 companies in Mrs. Sadow’s portfolio. The largest investments include Horizon Therapeutics Pub L and Cytokinetics Inc, together worth $234 billion.

$2.27 trillion Assets Under Management (AUM)

As of 7th February 2023, Pfm Health Sciences, L.P.’s top holding is 1,091,840 shares of Horizon Therapeutics Pub L currently worth over $124 billion and making up 5.5% of the portfolio value. In addition, the fund holds 2,399,545 shares of Cytokinetics Inc worth $110 billion, whose value fell approximately 0.1% in the past six months. The third-largest holding is Lilly Eli & Co worth $109 billion and the next is Centene worth $91.2 billion, with 1,112,480 shares owned.

Currently, Pfm Health Sciences, L.P.'s portfolio is worth at least $2.27 trillion. The total portfolio value may be much higher due to cash assets that are not publicly disclosed such as fixed income, real estate, or cash equivalents.

Careers at Pfm Health Sciences, L.P.

The Pfm Health Sciences, L.P. office and employees reside in San Francisco, California. According to the last 13-F report filed with the SEC, Darin Sadow serves as the General Counsel and Chief Compliance Officer at Pfm Health Sciences, L.P..

Recent trades

In the most recent 13F filing, Pfm Health Sciences, L.P. revealed that it had opened a new position in Biogen Inc and bought 155,659 shares worth $43.1 billion. This means they effectively own approximately 0.1% of the company. Biogen Inc makes up 2.6% of the fund's Health Care sector allocation and has grown its share price by 35.7% in the past year.

The investment fund also strengthened its position in Penumbra Inc by buying 177,244 additional shares. This makes their stake in Penumbra Inc total 360,030 shares worth $80.1 billion. Penumbra Inc soared 20.6% in the past year.

On the other hand, there are companies that Pfm Health Sciences, L.P. is getting rid of from its portfolio. Pfm Health Sciences, L.P. closed its position in Jazz Pharmaceuticals plc on 14th February 2023. It sold the previously owned 571,936 shares for $89.2 million. Darin Sadow also disclosed a decreased stake in Cytokinetics Inc by approximately 0.1%. This leaves the value of the investment at $110 billion and 2,399,545 shares.

One of the largest hedge funds

The two most similar investment funds to Pfm Health Sciences, L.P. are Periscope Capital and Cramer Rosenthal Mcglynn. They manage $2.26 trillion and $2.27 trillion respectively.


Darin Sadow investment strategy

Pfm Health Sciences, L.P.’s portfolio is diversified across 3 sectors. Currently, their heaviest sector is Health Care — making up 72.1% of the total portfolio value. The fund focuses on investments in the United States as 62.7% of the portfolio companies are based in the United States.

The majority of the companies in the fund’s portfolio are large-cap stocks. Stocks with a size of more than $10 billion in market cap make up 33% of the total holdings value. On the other hand, small-cap stocks make up only 1.3% of the portfolio. The average market cap of the portfolio companies is close to $54.8 billion.

The complete list of Pfm Health Sciences, L.P. trades based on 13F SEC filings

These positions were updated on February 14th based on the fund’s latest 13F filing. Quickly find out what the most recently closed or increased positions are.

Security Shares Owned Value Allocation
Horizon Therapeutics Pub L
No change
1,091,840
$124,251,392,000 5.48%
Cytokinetics Inc
2.66%
2,399,545
$109,947,152,000 4.85%
Lilly Eli & Co
No change
298,643
$109,255,555,000 4.82%
Centene Corp.
No change
1,112,480
$91,234,485,000 4.03%
Humana Inc.
No change
166,066
$85,057,345,000 3.75%
Axsome Therapeutics Inc
19.68%
1,092,831
$84,290,055,000 3.72%
Penumbra Inc
96.97%
360,030
$80,092,274,000 3.53%
Unitedhealth Group Inc
4.05%
116,067
$61,536,402,000 2.71%
Arcus Biosciences Inc
19.22%
2,703,287
$55,903,975,000 2.47%
Abbvie Inc
33.75%
329,344
$53,225,284,000 2.35%
Prothena Corp Plc
153.67%
875,464
$52,746,706,000 2.33%
Uniqure Nv
2.95%
2,302,314
$52,193,458,000 2.30%
Cardinal Health, Inc.
No change
639,783
$49,180,119,000 2.17%
Molina Healthcare Inc
No change
143,779
$47,478,701,000 2.09%
IQVIA Holdings Inc
3.33%
229,081
$46,936,406,000 2.07%
Cigna Corp.
No change
141,300
$46,818,342,000 2.07%
Danaher Corp.
No change
175,690
$46,631,640,000 2.06%
iRhythm Technologies Inc
No change
493,721
$46,246,846,000 2.04%
Syndax Pharmaceuticals Inc
212.45%
1,814,634
$46,182,435,000 2.04%
Biogen Inc
Opened
155,659
$43,105,090,000 1.90%
Merck & Co Inc
62.18%
367,634
$40,788,992,000 1.80%
Dynavax Technologies Corp.
No change
3,805,370
$40,489,137,000 1.79%
Mckesson Corporation
No change
105,811
$39,691,822,000 1.75%
Argenx Se
No change
104,732
$39,675,624,000 1.75%
Edwards Lifesciences Corp
56.74%
530,030
$39,545,538,000 1.74%
Astrazeneca plc
No change
576,800
$39,107,040,000 1.73%
Elevance Health Inc
57.05%
67,115
$34,427,982,000 1.52%
Thermo Fisher Scientific Inc.
No change
62,143
$34,221,529,000 1.51%
Avantor, Inc.
22.70%
1,607,612
$33,904,537,000 1.50%
Point Biopharma Global Inc
Opened
4,633,802
$33,780,417,000 1.49%
Waters Corp.
19.56%
94,624
$32,416,290,000 1.43%
Biomarin Pharmaceutical Inc.
63.02%
310,401
$32,123,399,000 1.42%
Intuitive Surgical Inc
Opened
114,450
$30,369,308,000 1.34%
Caribou Biosciences Inc
25.67%
4,459,783
$28,007,437,000 1.24%
Agilent Technologies Inc.
Opened
183,504
$27,461,374,000 1.21%
Karuna Therapeutics Inc
No change
130,293
$25,602,575,000 1.13%
Biocryst Pharmaceuticals Inc.
No change
2,162,411
$24,824,478,000 1.10%
Seagen Inc
31.87%
192,384
$24,723,268,000 1.09%
Johnson & Johnson
77.60%
137,746
$24,332,831,000 1.07%
HCA Healthcare Inc
Opened
91,945
$22,063,122,000 0.97%
Procept Biorobotics Corp
44.77%
517,526
$21,498,030,000 0.95%
Erasca Inc
18.43%
4,797,460
$20,677,053,000 0.91%
IVERIC bio Inc
1.27%
917,557
$19,644,895,000 0.87%
Arcellx Inc
Opened
616,515
$19,099,635,000 0.84%
Universal Hlth Svcs Inc
60.80%
124,421
$17,529,675,000 0.77%
Apellis Pharmaceuticals Inc
Opened
318,422
$16,465,602,000 0.73%
Icon Plc
48.34%
81,725
$15,875,081,000 0.70%
Charles Riv Labs Intl Inc
Opened
72,820
$15,867,478,000 0.70%
Dexcom Inc
Opened
135,465
$15,340,057,000 0.68%
Editas Medicine Inc
132.93%
1,466,732
$13,009,913,000 0.57%
Tenet Healthcare Corp.
53.26%
254,525
$12,418,275,000 0.55%
Pulmonx Corp
Opened
1,455,770
$12,272,141,000 0.54%
Oak Str Health Inc
8.65%
565,239
$12,158,291,000 0.54%
Generation Bio Co.
4.68%
2,903,192
$11,409,545,000 0.50%
Celcuity Inc
Opened
712,111
$9,976,675,000 0.44%
Essa Pharma Inc
299.74%
3,844,332
$9,687,717,000 0.43%
Adaptimmune Therapeutics Plc
46.83%
4,843,510
$7,071,525,000 0.31%
Praxis Precision Medicines I
15.77%
2,777,467
$6,610,371,000 0.29%
Blueprint Medicines Corp
Opened
130,366
$5,711,334,000 0.25%
Verve Therapeutics Inc
74.29%
217,302
$4,204,794,000 0.19%
COMPASS Pathways plc
29.75%
509,625
$4,092,289,000 0.18%
Laboratory Corp Amer Hldgs
Opened
13,561
$3,193,344,000 0.14%
Pmv Pharmaceuticals Inc
72.51%
333,716
$2,903,329,000 0.13%
Werewolf Therapeutics Inc
25.27%
1,293,293
$2,651,251,000 0.12%
Bluebird bio Inc
Opened
244,867
$1,694,480,000 0.07%
iTeos Therapeutics, Inc.
86.82%
70,922
$1,385,107,000 0.06%
Io Biotech Inc
76.49%
507,640
$1,167,572,000 0.05%
Keros Therapeutics, Inc.
Opened
15,999
$768,272,000 0.03%
Xenon Pharmaceuticals Inc
Opened
17,488
$689,552,000 0.03%
Bellus Health Inc
Opened
63,864
$524,962,000 0.02%
Jounce Therapeutics Inc
91.24%
345,926
$383,978,000 0.02%
Sana Biotechnology Inc
93.41%
62,776
$247,965,000 0.01%
Vectivbio Hldg Ag
Opened
25,541
$221,313,000 0.01%
Biohaven Ltd
Opened
10,988
$152,513,000 0.01%
Jazz Pharmaceuticals plc
Closed
571,936
$89,228,000
Iovance Biotherapeutics Inc
Opened
13,337
$85,223,000 0.00%
Pfizer Inc.
Closed
1,343,384
$70,434,000
Veeva Sys Inc
Closed
202,387
$40,081,000
Icu Med Inc
Closed
242,185
$39,813,000
Becton Dickinson & Co
Closed
130,697
$32,221,000
Nevro Corp
Closed
659,410
$28,902,000
Catalent Inc.
Closed
218,366
$23,428,000
Myriad Genetics, Inc.
Closed
1,177,250
$21,391,000
Baxter International Inc.
Closed
323,907
$20,805,000
Intellia Therapeutics Inc
Closed
163,280
$8,451,000
Sight Sciences Inc
Closed
776,281
$6,979,000
Sophia Genetics Sa
Closed
1,766,062
$6,393,000
Acadia Pharmaceuticals Inc
Closed
384,995
$5,425,000
Aerie Pharmaceuticals Inc
Closed
699,531
$5,246,000
Bcls Acquisition Corp
Closed
464,103
$4,595,000
Jiya Acquisition Corp
Closed
464,103
$4,585,000
Pardes Biosciences Inc
Closed
801,204
$2,460,000
No transactions found
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